This book covers modern statistical inference based on likelihood with applications in medicine, epidemiology and biology. Two introductory chapters discuss the importance of statistical models in applied quantitative research and the central role of the likelihood function. The rest of the book is divided into three parts. The first describes likelihood-based inference from a frequentist viewpoint. Properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic are discussed in detail. In the second part, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. Modern numerical techniques for Bayesian inference are described in a separate chapter. Finally two more advanced topics, model choice and prediction, are discussed both from a frequentist and a Bayesian perspective. A comprehensive appendix covers the necessary prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis.
Published by: Springer | Publication date: 11/12/2013Kindle book details: Kindle Edition, 376 pages
Gaussian Markov Random Fields: Throey and Applications (Chapman & Hall/CRC Monographs on Statistics & Applied Probability Book 104)
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Published by: CRC Press | Publication date: 04/16/2007Kindle book details: Kindle Edition, 280 pages
Statistical Methods for Spatio-Temporal Systems (Chapman & Hall/CRC Monographs on Statistics & Applied Probability Book 107)
Statistical Methods for Spatio-Temporal Systems presents current statistical research issues on spatio-temporal data modeling and will promote advances in research and a greater understanding between the mechanistic and the statistical modeling communities.Contributed by leading researchers in the field, each self-contained chapter starts with an introduction of the topic and progresses to recent research results. Presenting specific examples of epidemic data of bovine tuberculosis, gastroenteric disease, and the U.K. foot-and-mouth outbreak, the first chapter uses stochastic models, such as point process models, to provide the probabilistic backbone that facilitates statistical inference from data. The next chapter discusses the critical issue of modeling random growth objects in diverse biological systems, such as bacteria colonies, tumors, and plant populations. The subsequent chapter examines data transformation tools using examples from ecology and air quality data, followed by a chapter on space-time covariance functions. The contributors then describe stochastic and statistical models that are used to generate simulated rainfall sequences for hydrological use, such as flood risk assessment. The final chapter explores Gaussian Markov random field specifications and Bayesian computational inference via Gibbs sampling and Markov chain Monte Carlo, illustrating the methods with a variety of data examples, such as temperature surfaces, dioxin concentrations, ozone concentrations, and a well-established deterministic dynamical weather model.
Published by: Chapman and Hall/CRC | Publication date: 10/20/2006Kindle book details: Kindle Edition, 286 pages