This second edition of a bestseller details the manifestations, diagnosis and treatment of immune-related disease in the dog and cat. It is illustrated throughout in full color, to show and explain to the reader as clearly as possible the complicated principles of disease and immunodiagnostic tests, supported by clinical cases, gross and histopathology, cytology, hematology, immunohistochemistry and other immunological tests.
Published by CRC Press on 11/28/2011
Book details: 464 pages.
Viral vectors are superior tools for gene therapy and as a genetic vaccine platform because viruses have evolved to efficiently infect and transfer their genomes to cells. Several impressive successes in viral vector-based gene therapies have been reported in humans, including restoration of vision in patients with Leber’s congenital amaurosis by retinal gene transfer and cures for severe immune deficiencies by gene transfer to hematopoietic stem cells. However, the mammalian immune system has evolved in parallel to fend off invading pathogens such as viruses. Innate and antigen-specific adaptive immune responses against viral vectors and therapeutic transgene products pose serious hurdles for successful gene therapy. Pre-existing immunity in humans, resulting from prior exposure to the parent virus that forms the basis for the gene transfer vehicle may be derived from, often prevents efficient gene transfer. This problem also reduces our ability to use certain vectors for genetic vaccination or in anti-cancer therapy. For these reasons, the gene transfer community has been extensively studying the mechanisms of immune responses against viral vectors and has started to develop strategies and protocols to block or circumvent such responses. Choice, design and engineering of a vector as well as the route of administration/target tissue can be optimized/ altered to minimize immune responses or evade pre-existing immunity. Immune suppression and modulation strategies are being developed in order to minimize inflammation, prevent antibody or T cell responses against vectors, and to promote tolerance to therapeutic gene products. Combinations of these approaches will likely facilitate clinical applications of gene therapy for many target diseases and also aid in vaccine development.
Published by Frontiers E-books
Book details: 464 pages.
How well can you answer pet owners' questions about proper diet and feeding? Canine and Feline Nutrition, 3rd Edition describes the role of nutrition and its effects upon health and wellness and the dietary management of various disorders of dogs and cats. By using the book's cutting-edge research and clinical nutrition information, you'll be able to make recommendations of appropriate pet food and proper feeding guidelines. Pet nutrition experts Linda P. Case, MS, Leighann Daristotle, DVM, PhD, Michael G. Hayek, PhD, and Melody Foess Raasch, DVM, provide complete, head-to-tail coverage and a broad scope of knowledge, so you can help dog and cat owners make sound nutrition and feeding choices to promote their pets' health to prolong their lives. Tables and boxes provide quick reference to the most important clinical information. Key points summarize essential information at a glance. A useful Nutritional Myths and Feeding Practices chapter dispels and corrects common food myths. New clinical information covers a wide range of emerging nutrition topics including the role of the omega-3 and omega-6 fatty acid families in pet health and disease management. Coverage of pet food safety and pet food ingredients includes both commercially and home-prepared foods and provides answers to pet owners’ questions on these topics. Completely updated content reflects the latest findings in clinical nutrition research. Information regarding functional ingredients and dietary supplementation provides a scientifically based rationale for recommending or advising against dietary supplements. Guidelines for understanding pet food formulations and health claims differentiate between "market-speak" and actual clinical benefits for patients, with practice advice for evaluating and selecting appropriate foods.
Published by Elsevier Health Sciences on 05/21/2010
Book details: 576 pages.
Canine and Feline Infectious Diseases is a practical, up-to-date resource covering the most important and cutting-edge advances in the field. Presented by a seasoned educator in a concise, highly visual format, this innovative guide keeps you current with the latest advances in this ever-changing field. 80 case studies illustrate the clinical relevance of the major infectious disease chapters. Well-organized Major Infectious Diseases chapters break down content by etiologic agent and epidemiology, clinical signs and their pathophysiology, physical examination findings, diagnosis, treatment and prognosis, immunity, prevention, and public health implications. Over 80 case studies illustrate how the information provided can be applied in everyday practice. Logical approach to laboratory diagnosis guides you through all the steps needed to accurately diagnose and treat viral, bacterial, fungal, protozoal, and algal diseases. Practical protocols provided by expert clinicians guide you in the management of canine and feline patients suspected to have infectious diseases, including handling, disinfection, isolation, and vaccination protocols. Over 500 full color images – geographic distribution maps, life cycle drawings, and hundreds of color photographs – visually illustrate and clarify complex issues. Easy-to-understand tables and boxes make content quickly accessible, eliminating the need to sort through dense text for critical information in the clinical setting.
Published by Elsevier Health Sciences on 06/06/2013
Book details: 928 pages.
This comprehensive reference book contains the latest research and information on dog genetics. No similar book is currently available - this is the first high level research work on the topic.Written by the leading authorities in the field from Europe, the USA, Russia and Australia
Published by CABI on 06/25/2019
Book details: 564 pages.
Dogs are now arguably the most popular companion animals, and the general wellbeing of the family pet is of paramount importance to many people. Today far more veterinary surgeons are concerned with the welfare of dogs than with any other animal. Veterinary Notes for Dog Owners provides a detailed, authoritative and easily understood text for the professional breeder and pet owner alike, as well as for veterinary surgeons and nurses looking for clear, up-to-the minute explanations of sometimes complex issues. Twenty authors, all experts in their particular fields, have come together under the astute editorial guidance of leading veterinary surgeon Trevor Turner BVetMed, MRCVS, to cover all aspects of canine health care and management. There are detailed sections on general and inherited disease, the organ systems and infectious and parasitic diseases; on nutrition and feeding; on first aid, poisoning, and nursing the sick dog; canine dentistry and hernias; on behavior and behavioral problems. Invaluable advice on choosing a dog and building kennels is included as well as such topics as understanding pet insurance. This book is destined to become the standard work on canine health care and management, the essential manual for anybody who takes a serious interest in the welfare of dogs.
Published by Random House on 08/31/2011
Book details: 624 pages.
Bailey provides natural remedies for pet lovers to ensure their pets health and longevity.
Published by Morgan James Publishing on 11/01/2007
Book details: 178 pages.
This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: * Lymphoid organs and their anatomical disposition * Leukocytes and their markers * Leukocyte traffic and associated molecules * Cytokines * T cell receptors * Immunoglobulins * MHC antigens * Ontogeny of the immune system * Passive transfer of immunity * Neonatal immune responses * Non-specific immunity * Complement system * Mucosal immunity * Immunodeficiencies * Tumours of the immune system * Autoimmunity
Published by Academic Press on 05/21/1998
Book details: 673 pages.
In recent years there has been growing international focus on the importance of emerging and re-emerging arthropod-borne diseases in both human and veterinary medicine. Increasingly these diseases are being diagnosed and treated in veterinary practice. In this book the authors first discuss the overall significance of this group of diseases, plus arthropod biology and immunology, and current laboratory diagnostic methods, followed by individual chapters on each disease entity, grouped by causative organism (protozoan, bacterial, viral). Each chapter covers background etiology and epidemiology, including the role of wildlife species and zoonotic effects, pathogenesis, clinical signs, diagnosis and treatment. The book is illustrated throughout in color and contains photographs of clinical cases, hematology, cytology and gross and microscopic pathology. In short, the book provides an accessible guide to arthropod-borne infectious disease for veterinarians in practice and training.
Published by CRC Press on 04/11/2005
Book details: 128 pages.
The only complete resource on immunology for veterinary students and practitioners, Veterinary Immunology: An Introduction features a straightforward presentation of basic immunologic principles with comprehensive information on the most significant immunological diseases and responses seen in domestic animals. This meticulously updated new edition explores the latest advances in the field and provides a wealth of clinical examples that illustrate and clarify important concepts. Comprehensive coverage of vaccines and vaccine usage, allergies and allergic diseases, and autoimmunity and immunodeficiencies, prepare you for the multiple immunologic issues you will encounter in practice. A wealth of clinical examples clearly illustrate key concepts and offer practical strategies for diagnosing and treating immunologic disorders in the clinical setting. More than 500 full-color diagrams and illustrations visually demonstrate and clarify complex issues. Completely updated section on innate immunity includes new chapters on natural killer (NK) cells and systemic responses to infection to ensure you have the most up-to-date information. New information on genomics and molecular diagnostic techniques explores how the emerging field of genomics impacts disease resistance and immunology in general, as well as the diagnosis and treatment of immunological and infectious diseases. Updated content provides new information on well-recognized older diseases such as rheumatoid arthritis, systemic lupus, and inflammatory bowel disease, as well as current information on new diseases such as devil facial tumor disease and bovine neonatal pancytopenia. Expanded coverage brings you the latest knowledge on resistance to infection, such as vaccine usage, especially with respect to duration of immunity, the effects of key vitamins and lipids on immune responses, the effects of old age on immunity, and both antiviral and parasitic immunity. Diagnostic tests described throughout the text include a new section on the analysis of ELISA test data, as well as a brief summary of molecular diagnostic techniques. Coverage reflecting a significant change in the overall view of immunology provides you with the foundational knowledge needed to grasp the broad pattern of immunologic reactions and understand how the immune system functions as an interconnected network, rather than a series of independent pathways. New discussions of the critical importance of commensal bacteria and intestinal flora explain help you understand the importance of this normal flora with respect to antibacterial immunity, allergies, and autoimmunity, while at the same time providing a broader view of the animal body and its microflora as a "superorganism." A discussion of the importance of adipose tissue in immunity and inflammation addresses the epidemic of obesity in domestic pets and the extraordinary growth rates expected of domestic livestock. The section on inflammatory mechanisms has been divided into separate chapters focusing on the detection of invaders and the mediators of inflammation to incorporate the vast amount of new information on pattern recognition receptors and the ways in which they warn the body of microbial invasion.
Published by Elsevier Health Sciences on 12/27/2013
Book details: 568 pages.