Computer tools helped us uncover and understand potent protein toxins that empower bacterial pathogens against plants, animals and man. These toxins are potential drug targets and researchers can use them to make vaccines. New toxin knowledge aids the long-term goal of finding alternatives to antibiotics, to which pathogens are becoming more resistant. The toxins share similar structure despite low sequence identity, so our search links sequence and structure features. We present a ranked list and computational characterization of six new toxins combined with cell-based tests.
Uploaded by rfieldhouse on 01/05/2011
Digital publication details: 19 pages.
In the current data-rich era, making the leap from sequence data to knowledge is a task that requires an elegant bioinformatics toolset to pinpoint pressing research questions. Therefore, a strategy to expand important protein-family knowledge is required, particularly in cases in which primary sequence identity is low but structural conservation is high. For example, the mono-ADP-ribosylating toxins fit these criteria and several approaches have been used to accelerate the discovery of new family members. The strategy evolved from conduction of PSI–BLAST searches through to the combination of secondary-structure prediction with pattern-based searches. However, a newly developed tactic, in which fold recognition dominates, reduces reliance on sequence similarity and advances scientists toward a true structure-based protein-family expansion methodology.
Uploaded by rfieldhouse on 09/24/2008
Digital publication details: 11 pages.
Antibiotic resistance is on the rise, making harmful bacteria armed with protein toxins increasingly worrisome, says a University of Guelph professor who’s trying to find new ways to identify these toxins, figure out how they work and disarm them.
Uploaded by rfieldhouse on 04/06/2012
Digital publication details: 1 pages.
This second edition of Introduction to Human Nutrition is an update of the very basic foundations for the study of human nutrition. Although little has changed, all authors have made whatever updates are necessary and we have made some re-arrangements of some chapters. The study of human nutrition at universities across the globe is rapidly expanding as the role of diet in health becomes more evident. Indeed, the sequencing of the human genome has highlighted the narrower range of genes controlling human biology, emphasising the critically important role of the environment including diet in human health. Moreover, we now recognize the important role that diet plays in interacting with our genome both in utero and in the immediate period of post natal development.
Uploaded by oumfs on 04/16/2013
Digital publication details: 386 pages.
The fact is that the cytokines form an informative network, for some ways very similar to the Internet, that capillary connects, as knots to the network, cellular systems also different. The study of this network is important for understanding the evolution of the pathogenesis of many chronic inflammatory diseases.
Uploaded by ankushsharma4 on 03/29/2012
Digital publication details: 24 pages.