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Chemistry and Water
After air, water is the most crucial resource for human survival. To achieve water sustainability, we will have to deal with its scarcity and quality, and find ways to reclaim it from various sources. Chemistry and Water: The Science Behind Su

Modern Instrumental Analysis
Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions* Covers the fundamentals of instrumentation as well as key applications * Each chapter includes review questions that reinforce concepts * Serves as a quick reference and comprehensive guidebook for practitioners and students alike

Handbook of Pharmaceutical Analysis by HPLC
High pressure liquid chromatography-frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected

Chromatography and Separation Science
The basic objectives of this book are to: provide basic information on chromatography and separation science; show how simple extraction and partition processes provide the basis for development of chromatography and separation science; describe the role of chromatography and separation science in various fields; discuss the role of chromatography and separation science in development of new methodology; and present new evolving methods and how to select an optimum method. The book covers the fundamental physical and chemical phenomena involved in separations Provides a concise overview of the basics of transport phenomena and thermodynamics Shows the importance of chromatography within separation science

Handbook of Bioseparations
It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories. Key Features* Covers bioseparations of proteins, nucleic acids, and monoclonal antibodies* Encompasses both analytical and process-scale methods* Elucidates the importance of engineering process control* Details selection of plant and process equipment* Addresses economic considerations* Discusses future developments

HPLC Method Development for Pharmaceuticals
High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge* Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory* Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities)* Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

Preparative Chromatography for Separation of Proteins
Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. Covers broad aspects of preparative chromato

Handbook of Isolation and Characterization of Impurities in Pharmaceuticals
The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization- Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.

Capillary Electrophoresis Methods for Pharmaceutical Analysis
Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control- Provides current status and future developments in CE analysis of pharmaceuticals- Explains how to develop and validate methods- Includes major pharmaceutical applications including assays and impurity testing.

Monitoring Water Quality
Monitoring Water Quality is a practical assessment of one of the most pressing growth and sustainability issues in the developed and developing worlds: water quality. Over the last 10 years, improved laboratory techniques have led to the

Chemistry and Water: The Science Behind Sustaining the World's Most Crucial Resource
After air, water is the most crucial resource for human survival. To achieve water sustainability, we will have to deal with its scarcity and quality, and find ways to reclaim it from various sources. Chemistry and Water: The Science Behind Sustaining the World's Most Crucial Resource applies contemporary and sophisticated separation science and chromatographic methods to address the pressing worldwide concerns of food production, efficient energy use, and potable, readily available fresh water across global communities. Edited and authored by world-leading analytical chemists, the book presents the latest developments in research on a broad range of topics, including water quality and pollution, water treatment technologies and practices, water shortage and energy production, water quality and energy production, challenges to achieving sustainable water supplies, water reclamation techniques, and wastewater reuse. Explores the role water plays to assure our survival and maintain lifeContains more than 75 figures and illustrations that aid in the retention of key conceptsMulti-authored and edited by world leaders in chemistry and water researchAddresses the use of the nexus of food, energy, and water to ensure sustainability

Handbook of Water Purity and Quality
This work provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book first provides an over

Food, Energy, and Water
How will chemists of the future balance competing concerns of environmental stewardship and innovative, cost-effective product development? For chemists to accept the idea that environmental quality and economic prosperity can be intertwined, the

Water Reclamation and Sustainability
Many hydrological, geochemical, and biological processes associated with water reclamation and reuse are poorly understood. In particular, the occurrence and effects of trace organic and inorganic contaminants commonly found in reclaimed water nec

Bioseparations of Proteins
This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is th

Comprehensive Water Quality and Purification
This major reference work provides a rich source of methods for analyzing water to assure its safety from natural and deliberate contaminants, including those that are added because of carelessness of human endeavors. Human development has great i

Handbook of Modern Pharmaceutical Analysis
This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the quality of drug products is assured from the point of discovery until the patient uses the drug. Cove

Chiral Separation Methods for Pharmaceutical and Biotechnological Products
Discusses chiral separations and offers guidance for selecting the optimum method for desired resultsChiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds.

Handbook of Modern Pharmaceutical Analysis
Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, ca
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